From the Editor

Evidence, limes, and cement

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In the 1990s, Sackett et al1 popularized the term evidence-based medicine, ie, the evaluation and use of clinical research in decision-making for individual patients. Some have not embraced evidence-based medicine as the be-all and end-all of clinical decision-making, and we should not expect clinical studies to tell us what to do in every decision that we make at the bedside. Nonetheless, almost everyone accepts the well-done randomized, placebo-controlled study as the most powerful tool in the evidence-based medicine toolbox.

In 1753, Lind2 described how he gave fresh fruit vs cider, vinegar, sulfuric acid, seawater, or barley water to 12 sailors aboard the HMS Salisbury in an effort to find a cure for scurvy. This landmark clinical trial has been hailed as an example of how clinical research can dramatically alter clinical practice. Yet practice did not change aboard British naval ships until almost 50 years after Lind’s treatise was published.3

For many reasons, randomized clinical trials may not immediately affect what physicians do. Sometimes, physicians believe that the trials were not well designed or well conducted, or that the results do not apply to their patients. I briefly discussed some limitations of evidence-based clinical decision-making in our September 2009 issue.4

Another reason is that the conclusions from some trials do not jibe with the experience of seasoned clinicians. That is why, this month, I have asked two physicians, a rheumatologist5 and a spine surgeon,6 to comment on how two studies7,8 have influenced their clinical practice. Both studies concluded that vertebroplasty (injecting cement to shore up osteoporotic vertebrae) was no more beneficial than a sham procedure in patients with vertebral compression fractures. Neither physician is ready to completely abandon vertebroplasty on the basis of these two studies. Thus, it seems that published evidence may provide us guidance and fruit for discussion, but does not give us certainty.

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The Role of Incretin-Based Therapies in Treating Patients with Type 2 Diabetes Mellitus

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