Acute leukemia with a very high leukocyte count: Confronting a medical emergency
Navneet S. Majhail, MD
Department of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis
Alan E. Lichtin, MD
Department of Hematology and Medical Oncology, The Cleveland Clinic Foundation
Address: Alan E. Lichtin, MD, Department of Hematology & Medical Oncology, R35, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail firstname.lastname@example.org
ABSTRACTFrom 5% to 30% of adult patients with acute leukemias present with hyperleukocytosis—very high white blood cell counts (> 100,000 cells/mm3)—and symptoms of leukostasis. These conditions are a medical emergency that needs prompt recognition and initiation of therapy to prevent respiratory failure or intracranial hemorrhage. Patients should be referred as soon as possible for induction chemotherapy and leukapheresis.