Proceedings of the 10th International Vasculitis and ANCA Workshop


Program Chairmen and Editors:
Gary S. Hoffman, MD, and John H. Stone, MD, MPH



A. Immune Predisposition and Infectious Etiology of Systemic Vasculitis
Moderators: Coen Stegeman and Herbert Virgin

Keynote Presentation
Host and viral genes that control herpesvirus vasculitis
Herbert W. Virgin IV

Plenary Session Abstracts (1-3)
1-090. Induction of pauci-immune necrotizing and crescentic glomerulonephritis (NCGN) by intravenous administration of anti-myeloperoxidase (anti-MPO) antibodies to recombinase activating gene-2 deficient (RAG-2 -/-) mice
J.C. Jennette, H. Xiao, P. Heeringa, Z. Liu, P. Hu, M. Zhao, Y. Aratani, R.J. Falk

2-091. Induction of necrotizing and crescentic glomerulonephritis (NCGN) and small-vessel vasculitis (SVV) by adoptive transfer of anti-myeloperoxidase (anti-MPO) lymphocytes into recombinase activating gene-2 deficient (RAG-2 -/-) mice
H. Xiao, P. Heeringa, Z. Liu, P. Hu, M. Zhao, Y. Aratani, R.J. Falk, J.C. Jennette

3-049. Contribution of activated neurotrophils and MPO-ANCA to the development of crescentic glomerulonephritis in SCG/KJ mice
A. Ishida-Okawara, T. Ito-Ihara, T. Ono, E. Muso, K. Saiga, K. Nemoto, K. Suzuki

Keynote Presentations
Known causes of vasculitis in man
Stanley J. Naides

HCV and cryoglobulinemic vasculitis
Clodoveo Ferri, A.L. Zignego, D. Giuggioli, M. Sebastiani, M. Cazzato, A. Antonelli, L. La Civita, P. Fadda, G. Longombardo, and S. Pileri

Infections in primary vasculitides
Jan W. Cohen Tervaert

Plenary session Abstracts (4-5)
4-093. Staphylococcal toxic-shock-syndrome-toxin-1 (TSST-1) is a risk factor for disease relapse in Wegener's granulomatosis
E.R. Popa, B. van der Meer, J. Arends, W.M. Manson, N.A. Bos, C.G.M. Kallenberg, J.W. Cohen Tervaert, C.A. Stegeman

5-104.Chlamydia pneumoniae and giant-cell arteritis: Failure to detect Chlamydia pneumoniae in temporal artery biopsies by polymerase chain reaction
M.J. Regan, B.J. Wood, Y.-H. Hsieh, M.L. Theodore, T.C. Quinn, D.B. Hellmann, W.R. Green, C.A. Gaydos, J.H. Stone

B. Patterns of Injury: Implications for Pathogenesis
Moderators: Loïc Guillevin and Cornelia Weyand

Keynote Presentations
Pathogenic mechanisms in giant cell arteritis
Cornelia M. Weyand and Jörg J. Goronzy

Implications for pathogenesis of patterns of injury in small- and medium-sized-vessel vasculitis
J. Charles Jennette

Plenary Session Abstracts (6-7)

6-037. Superantigenic activation of T lymphocytes and endothelial cells: A mechanism for superantigen-induced vasculitis
P.A. Brogan, V. Shah, N. Klein, M.J. Dillon

7-108. Analysis of autoantibody repertoires in small and medium sized vessel vasculitis: Evidence for disease-specific perturbations in classic polyarteritis nodosa (PAN), micropolyangiitis (MPA), Churg-Strauss syndrome (CSS) and Wegener's granulomatosis (WG)
Y. Chanseaud, L. Guillevin, M. Kambouchner, M.C. Boissier, L. Mouthon

Keynote Presentation
Granuloma formation, implications for the pathogenesis of vasculitis
Michael C. Sneller

Plenary Session Abstracts (8-9)
8-052. Chemokine receptor expression on CD4+ and CD8+ memory T-cells and in granulomas in Wegener's granulomatosis
P. Lamprecht, A. Erdmann, A. Mueller, E. Csernok, H. Bruehl, W.L. Gross, M. Mack

9-016. Genetic resistance to Wegener's granulomatosis—a role for CCR5 in patients without antineutrophil cytoplasmic antibodies
Y. Zhou, D. Huang, C. Farver, G. Hoffman

Keynote Presentation
Endothelial cell biology, perivascular inflammation, and vasculitis
Maria C. Cid

Plenary Session Abstract (10)
10-023. Novel effects of inflammatory cell proteases on vascular endothelia
G.A. Preston, W.F. Pendergraft, J.J. Yang, J.C. Jennette, R.J. Falk

C. Possible Role of ANCA and AECA in Select Forms of Systemic Vasculitis
Moderators: Wolfgang Gross and Caroline Savage

Keynote Presentation
Understanding the pathogenesis of ANCA: Where are we today?
Gloria A. Preston, Jia Jin Yang, Hong Xiao, and Ronald J. Falk

Plenary Session Abstracts (11-12)
11-027. TNF-alpha accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism
R. Kettritz, J. Scheumann, Y. Xu, F.C. Luft, H. Haller

12-071. Membrane expression of neurotrophil proteinase 3 (PR3) is associated with relapse in PR3-ANCA related vasculitis
A.A. Rarok, C.A. Stegeman, P.C. Limburg, C.G.M. Kallenberg

Keynote Presentation
ANCA subsets: Influence on disease phenotype
Ulrich Specks

Plenary Session Abstract (13)
13-096. Sequential epitope mapping of the myeloperoxidase antigen
D.M. Wynn, J.A. James

Keynote Presentation
Genetics of ANCA-associated vasculitis
Cees G.M. Kallenberg, Agnieszka Rarok, and Coen A. Stegeman

Plenary Session Abstracts (14-15)
14-028. Membrane expression of proteinase 3 is genetically controlled
A. Schreiber, A. Bushjahn, F.C. Luft, R. Kettritz

15-015. Genetic polymorphisms in TNF, IL-1, IL-6 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) in Wegener's granulomatosis (WG)
Y. Zhou, D. Huang, G.S. Hoffman

Keynote Presentation
Classification of anti-endothelial cell antibodies into antibodies against microvascular and macrovascular endothelial cells: The pathogenic and diagnostic implications
Yehuda Shoenfeld

Plenary Session Abstract (16)
16-029. HMG-COA reductase inhibitors decrease ANCA-mediated activation of human neutrophils
M. Choi, S. Rolle M. Rane, H. Haller, F.C. Luft, R. Kettritz


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