Conivaptan Shown to Reverse Hyponatremia

After 5 days of treatment, serum sodium levels were significantly higher in both treatment groups, compared with control patients, said Peter Gross, M.D., professor of medicine and nephrology at the Carl Gustav Carus University Clinic in Dresden, Germany. Sodium levels rose in a dose‐dependent fashion, and the increases were similar to those seen in the two U.S. studies. The effects on sodium levels were similar regardless of volemic status at baseline and hyponatremia etiology. Treatment with conivaptan was well tolerated, with a low rate of drug‐related adverse effects and few discontinuations due to adverse effects.