Treg cells and serum Treg-associated cytokines play an important role in PsA pathogenesis
Key clinical point: In patients with psoriatic arthritis (PsA), the percentages of some Treg cell subgroups and the levels of Treg-related cytokines, such as transforming growth factor-beta (TGFβ), were decreased.
Major finding: Compared with control individuals without PsA, patients with PsA had a similar proportion of Treg cells (P = .071), with no significant difference in the proportion of OKT8+ Treg cells (P = .679) and significantly decreased CD4+ Treg cells (standardized mean difference [SMD] −1.501; P = .023). TGFβ levels were lower in patients with PsA vs healthy controls (SMD −2.199; P = .003).
Study details: Findings are from a meta-analysis of 12 studies including 525 patients with PsA and 414 control individuals.
,Disclosures: This study was supported by the National Natural Science Foundation of China and other sources. The authors declared no conflict of interests.
Source: Su QY et al. Peripheral Treg levels and transforming growth factor-β (TGFβ) in patients with psoriatic arthritis: A systematic review meta-analysis. Adv Ther. 2022 (Oct 26). Doi: 10.1007/s12325-022-02337-5