Causal link between Crohn’s disease and PsA exists

Key clinical point: Inflammatory bowel disease (IBD), particularly Crohn's disease, is a causal risk factor for psoriatic arthritis (PsA).

Major finding: Genetically predicted IBD was associated with a higher risk for PsA (pooled odds ratio [OR] 1.11; P = .003) with the risk being majorly mediated by Crohn’s disease (OR 1.12; P = .002) and not ulcerative colitis (P = .70).

Study details: Findings are from a bidirectional 2-sample mendelian randomization study including 12,882 patients with IBD and 21,770 matched-controls and 5621 patients with psoriasis and 2063 patients with PsA who were compared with 252,323 controls.

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Disclosures: This study did not report any source of funding. The authors declared no conflicts of interest.

Source: Freuer D et al. Association between inflammatory bowel disease and both psoriasis and psoriatic arthritis: A bidirectional 2-sample mendelian randomization study. JAMA Dermatol. 2022 (Sep 14). Doi: 10.1001/jamadermatol.2022.3682