Key clinical point: Increased subcutaneous abdominal fat is independently associated with cutaneous allodynia (CA), a marker of central sensitization in patients with migraine.
Major finding: Migraine patients with CA had a higher proportion of abdominal fat values than patients without CA ( P = .04). The use of migraine prophylaxis (odds ratio [OR], 3.26), abdominal fat (OR, 1.13), and sleep disorders (OR, 1.13) were independent risk factors for the development of CA.
Study details: This prospective study investigated the association between CA and percentages of body fat and abdominal fat in 80 patients with migraine and 39 nonmigraine controls.
Disclosures: No study sponsor was identified. Allergan Inc. funded editorial assistance and statistical advice. María Rosario Luquin has received honoraria from TEVA, Zambon, AbbVie, and Bial for activities unrelated to the study. Pablo Irimia has received honoraria from Allergan, Novartis, Lilly, and Teva Pharmaceuticals as a consultant and speaker.
Citation: Mínguez-Olaondo A et al. J Headache Pain. 2020 Feb 4. doi: 10.1186/s10194-020-1082-0 .