Literature Monitor

Resting State Functional Connectivity Signals Medication Resistance

Epilepsy Res; 2019 Jan; Pressl et al.


Altered thalamo-hippocampal resting state functional brain connectivity may serve as a biomarker to signal treatment resistance in patients with temporal lobe epilepsy (TLE) suggests a recent study of 286 patients with epilepsy.

  • Researchers from Rockefeller University reviewed data from a database that included resting state functional MRI readings.
  • The analysis included seizure characterization, EEG indications of lateralization, and localization of seizure foci.
  • The investigators compared records from patients with well-controlled TLE to those with treatment resistant disease and healthy controls.
  • Treatment resistant patients had a significant bilateral decrease in thalamo-hippocampal functional connectivity.

Pressl C, Brandner P, Schaffelhofer S, et al. Resting state functional connectivity patterns associated with pharmacological treatment resistance in temporal lobe epilepsy. Epilepsy Res. 2019;149:37-43.

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