Literature Monitor

Unique MRI Findings in Juvenile Myoclonic Epilepsy

Epilepsia; ePub 2018 Oct 3; Garcia-Ramos et al.


The cortical regions of the brains of patients with juvenile myoclonic epilepsy (JME) are more likely to be disassociated from subcortical structures, according to a recent study that compared the MRI readings of JME patients to those of normal children.

  • Investigators from the University of Wisconsin School of Medicine compared 21 children with JME to 22 healthy controls over a 2 year period.
  • Normal children had modular cortical development and network integration between cortical and subcortical regions.
  • Patients with epilepsy had a less modular cortical network that was disassociated from subcortical structures.
  • Children with JME were also found to have weaker modules or communities, as indicated by higher clustering and lower modularity indices.

Garcia-Ramos C, Dabbs K, Lin JJ, et al. Progressive dissociation of cortical and subcortical network development in children with new onset juvenile myoclonic epilepsy [Published online ahead of print Oct 3, 2018]. Epilepsia.

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