The presence of interictal ripples in an intracranial EEG may serve as useful biomarkers suggests an analysis of data from 27 children who underwent epilepsy surgery.
- The average rate of onset ripples located inside a resected area of the brain predicted a patient’s outcome (odds ratio, 5.37, P=.02)
- Mean onset ripple rate was associated with the Engel class metric for measuring outcomes.
- Resection of the onset ripple zone was linked to good surgical outcomes ( P=.047).
- On the other hand, there was no correlation between spread ripple zone, isolated-ripple zone, or spike zones and outcomes.
Tamilia E, Park EH, Percivati S, et al. Surgical resection of ripple onset predicts outcome in pediatric epilepsy [published online ahead of print July 18, 2018]. Ann Neurol. 2018: doi: 10.1002/ana.25295