Literature Monitor

Interictal Ripples Predict Surgical Outcomes

Ann Neurol; ePub 2018 Jul 18; Tamilia et al.


The presence of interictal ripples in an intracranial EEG may serve as useful biomarkers suggests an analysis of data from 27 children who underwent epilepsy surgery.

  • The average rate of onset ripples located inside a resected area of the brain predicted a patient’s outcome (odds ratio, 5.37, P=.02)
  • Mean onset ripple rate was associated with the Engel class metric for measuring outcomes.
  • Resection of the onset ripple zone was linked to good surgical outcomes ( P=.047).
  • On the other hand, there was no correlation between spread ripple zone, isolated-ripple zone, or spike zones and outcomes.

Tamilia E, Park EH, Percivati S, et al. Surgical resection of ripple onset predicts outcome in pediatric epilepsy [published online ahead of print July 18, 2018]. Ann Neurol. 2018: doi: 10.1002/ana.25295

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