Literature Monitor

Ketogenic Diet Found Effective and Well Tolerated in Children With RSE

Epilepsy Res; 2018 Aug; Arya et al.


A ketogenic diet appears to be effective for children with refractory status epilepticus (RSE) suggests a small trial that included 14 patients.

  • A study conducted by the Status Epilepticus Research Group from January 2011 to December 2016 found that 71% of patients with refractory status epilepticus who received a ketogenic diet experienced seizure resolution, verified by EEG findings, within 7 days of starting the regimen.
  • 79% of the children with RSE were weaned off enteral infusions of the diet within 14 days.
  • Possible adverse effects from the ketogenic diet occurred in 3 of 14 patients, including gastrointestinal paresis and elevated triglyceride levels.
  • The regimen produced ketosis within a median of 2 days after it was initiated.
  • By 3 months, 4 patients were still seizure free and 3 had fewer seizures.

pediatric Status Epilepticus Research Group (pSERG). Efficacy and safety of ketogenic diet for treatment of pediatric convulsive refractory status epilepticus. Epilepsy Res. 2018;144:1-6.

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