Literature Monitor

Pediatric Refractory Status Epilepticus Still Challenges Clinicians

Seizure; ePub 2018 May 19; Vasquez et al.


Pediatric refractory status epilepticus (RSE) and super refractory status epilepticus (SRSE) remain life-threatening disorders whose etiology and effective management are elusive according to a review in Seizure.

  • RSE is defined as a disorder that doesn’t respond to first and second line antiepileptic agents.
  • SRSE refers to status epilepticus that continues for at least 24 hours after anesthetic agents have been given or which recurs once the drugs are stopped.
  • The evidence to support current treatment options is not based on randomized clinical trials but instead relies on case series and expert opinions.
  • The most common treatment for both disorders is continuous IV infusion of anesthetic drugs but the best dosing and the optimal administration rate remain controversial.
  • Some clinicians have used non-drug approaches to RSE and SRSE but the evidence supporting these options is limited.

Vasquez A, Farias-Moeller R, Tatum W. Pediatric refractory and super refractory status epilepticus [Published online ahead of print May 19, 2018]. Seizure. DOI:

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