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Glucose Hypometabolism Found in Pediatric Drug-Resistant Epilepsy

Epilepsia; ePub 2018 May 22; Govil-Dalela et al.


Children with drug-resistant epilepsy seem to have a lobar pattern of glucose hypometabolism according to PET scans performed on 41 patients with the disorder.

  • Baseline positron emission tomography (PET) scans were performed on children with drug resistant epilepsy with a median age of 4.7 years.
  • A follow-up PET scan was done 4.3 years (median) later.
  • Children with space-occupying lesion-related epilepsy were not included in the study, nor were patients with progressive neurological disorders.
  • Twenty-four children had unilateral glucose hypometabolism and 13 had bilateral hypometabolism at baseline.
  • Follow-up PET scans revealed that 63% had interval expansion of the hypometabolic region of their brain; said expansion was associated with persistent seizures.

Govil-Dalela T, Kumar A Behen ME, Chugani HT, Juhász C. Evolution of lobar abnormalities of cerebral glucose metabolism in 41 children with drug-resistant epilepsy [Published online ahead of print May 22, 2018]. Epilepsia. doi: 10.1111/epi.14404.

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