A cross-sectional analysis of epilepsy intervention trials suggests there may be bias in the reporting of these investigations according to a recent review of the research.
- Investigators analyzed 126 epilepsy intervention trials, comparing two reporting periods: 2008 to 2011 and 2012 to 2015.
- Twenty five percent of the trials were not reported (31/126).
- 72 of the 126 trials were conducted in at least one US center.
- 56 of 72 trials (78%) met the US Food and Drug Administration’s Amendments Act requirements.
- Researchers found that the time it took to report trial results had become shorter over time, when comparing 2008-2011 to 2012-2015.
- However, only a third of the trials (19/56) reported their results within the FDA’s mandated one-year time frame.
Rayi A, Thompson S, Gloss D, Malhotra K. Reporting bias in completed epilepsy intervention trials: a cross-sectional analysis. Epilepsy Res. 2018;143:1-6