Literature Monitor

Linking EEG Oscillations to Epileptic Spasms

Epilepsia; 2018 March; Iimura et al.


The occurrence rate of high-frequency oscillations is higher in children with drug-resistant multilobar epilepsy who experience epileptic spasms, when compared with those who do not, according to a study published in Epilepsia.

  • Researchers found that the number of electrodes with high-rate fast ripple (FR) amplitude and the modulation index of coupling between slow and fast oscillations in all electrodes were significantly higher in children with epileptic spasms.
  • The investigation involved 24 pediatric patients with drug-resistant multilobar onset epilepsy who had intracranial video EEGs done before multilobar resection.
  • The modulation index was highest in 5 frequency bands among both epileptic spasm and nonepileptic spasm prone children.
  • Researchers concluded that the greater number of high-rate FR electrodes provided evidence that there was more widespread epileptogenicity in the spasming patients, compared to those without spasms.
  • Children with epileptic spasms who were free of seizures after surgery had strong coupling between slow oscillations and FRs.

Iimura Y, Jones K, Takada L, et al. Strong coupling between slow oscillations and wide fast ripples in children with epileptic spasms: Investigation of modulation index and occurrence rate. Epilepsia. 2018;59(3):544-554.

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