Literature Monitor

Perivascular Spaces May Offer Epilepsy Clues

Seizure; 2018 Jan; Feldman et al.


Differences in the perivascular spaces in the brain may serve as a biomarker for patients with epilepsy, assisting clinicians in determining the impact of the disorder, according to a comparison of MRI images from healthy controls and patients.

  • Researchers used 7T magnetic resonance imaging to evaluate the brains of 21 patients with epilepsy and 17 healthy controls.
  • Perivascular spaces were marked with the use of Osirix image analysis software.
  • Investigators calculated the asymmetry index for each region of the brain and reported a maximum asymmetry index for patients and controls.
  • Significant differences were found in the maximum asymmetry index between patients with epilepsy and controls ( P=.016).
  • In nearly 3 of 4 patients (72%), the area or lobe of the brain that displayed the maximum perivascular space asymmetry was also the area that contained the suspected area for the onset of seizures.

Feldman RE, Rutland JW, Fields MC, et al. Quantification of perivascular spaces at 7T: A potential MRI biomarker for epilepsy. Seizure. 2018;54:11-18.

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