Literature Monitor

Linking PNES to Co-Existing Disorders and Medications

Epilepsia; 2017 Nov; Kerr et al.


Psychogenic nonepileptic seizures (PNES) may be distinguished from other seizure disorders with the help of a patient’s medical history and medication history according to a data analysis involving more than 1300 patients with confirmed diagnoses.

  • 1365 adult patient case reports were reviewed, all of which involved video-electroencephalography confirmed diagnoses that were performed at one medical center.
  • Co-existing disorders that can help separate PNES from epilepsy included asthma, chronic pain, and migraines.
  • Comorbidities associated with epileptic seizures included diabetes and nonmetastatic neoplasm.
  • Overall, the number of co-existing conditions and medications rather than any specific condition was more predictive.
  • The analysis was also able to differentiate PNES from epileptic seizures with a prospective accuracy of 78%.

Kerr WT, Janio EA, Braesch CT, et al. Identifying psychogenic seizures through comorbidities and medication history. Epilepsia. 2017;58(11):1852-1860.

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