Literature Monitor

Extending Insular Glioma Resection Cuts Seizure Recurrence

Neurosurgery; ePub 2017 Nov 8; Wang et al.


In patients who have had surgical resection of an insular glioma, the wider the extent of the resection, the longer they remain free from seizures, according to a study from the department of neurological surgery at the University of California, San Francisco (UCSF).

  • The analysis included 109 patients who had surgery for insular tumors from 1997 to 2015 at UCSF.
  • At final follow-up, 42 patients (39%) remained seizure free.
  • Increasing the extent of the resection predicted freedom from seizures.
  • The analysis also revealed that performing a second resection provided even greater seizure control; 8/22 patients with recurrent seizures no longer had them after the second surgery.
  • Patients who experienced a second seizure after resection were more likely to have had tumor progression.

Wang DD, Deng H, Hervey-Jumper SL, Molinaro AA, Chang EF, Berger MS. Seizure outcome after surgical resection of insular glioma. [Published online ahead of print Nov 8, 2017] Neurosurgery. doi: 10.1093/neuros/nyx486.

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