High frequency oscillations (HFOs) in certain regions of the brain have been associated with epilepsy. A recent review of the literature on HFOs is shedding new light on their possible role in the pathophysiology of the disease.
- Advances in recording technology and optogenetics have enhanced researchers’ ability to study HFOs.
- Substrates of HFOs linked to epilepsy have been identified with the help of sophisticated computer models.
- In the past, HFOs have been studied in animals and patients with temporal lobe epilepsy, but HFOs have recently been reported in patients with other types of seizures, including neocortical epilepsy, genetically induced epilepsy, and infantile spasms.
- High resolution in vivo imaging, optogenetics, and chemogenetic techniques are poised to help future investigators gain even deeper insights into the role of HFOs in seizures and epilepsy.
- The reviewers postulate that as investigators gain a better understanding of how HFOs are involved in the pathogenesis of epileptic disorders, it will allow them to better classify these diseases and improve diagnosis and treatment.
Jiruska P, Alvarado-Rojas C, Schevon CA, et al. Update on the mechanisms and roles of high-frequency oscillations in seizures and epileptic disorders. Epilepsia. 2017;58(8):1330-1339.