Literature Monitor

Siblings Respond Similarly to the Same AED

Epilepsy Res; 2017 Oct; Ueda et al.


Siblings tend to have a similar response to antiepileptic drugs (AEDs) suggests a study that compared drug response in sibling pairs. Details of the investigation include the following:

  • Investigators collected records from a single-center database that included patients with a diagnosis of epilepsy in which their last names, addresses, and parents’ names were matched to determine the existence of siblings with the same disease.
  • Twenty-eight sibling pairs were identified, along with 2 sibling trios with epilepsy.
  • Seventeen of the sibling pairs had been taking the same initial AED, while 15 pairs had the same type of epilepsy.
  • When at least one sibling in a pair improved on an initial AED, the other sibling was more likely to respond if they were taking the same AED compared with those who were taking a different AED.
  • While a positive response to an AED predicted success in a sibling taking the same drug, investigators pointed out that their study was retrospective and involved a small sample, which is why they recommended larger prospective trials.

Ueda K, Serajee F, Rajilich J, Taraman S, Steckling L, Huq AM. Sibling response to initial antiepileptic medication predicts treatment success. Epilepsy Res. 2017;136:84-87.

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