Intracranial deep brain stimulation (DBS) may offer some benefit to patients with epilepsy who do not respond to more conservative therapy, but most of the evidence comes from short-term randomized controlled trials, according to a recent review from the Cochrane Library. Experts concluded that anterior thalamic DBS, responsive ictal onset zone stimulation, and hippocampal DBS can reduce the frequency of seizures in patients with refractory epilepsy.
Sprengers M, Vonck K, Carrette E, Marson AG, Boon P. Deep brain and cortical stimulation for epilepsy. Cochrane Database Syst Rev . 2017 Jul 18;7:CD008497.