A 2-year study of 175 patients with partial-onset seizures showed that responsive neurostimulation using the RNS® System was not associated with cognitive decline. There was modest cognitive improvement in response to neurostimulation. The areas of improvement were related to the region of the brain from which seizures arose and where neurostimulation was delivered.
Loring DW, Kapur R, Meador KJ, Morrell MJ. Differential neuropsychological outcomes following targeted responsive neurostimulation for partial-onset epilepsy. Epilepsia. 2015; doi:10.111/epi.13191.