Atorvastatin plus nortriptyline: A promising combination for migraine therapy

Key clinical point: Compared with nortriptyline alone, its combination with atorvastatin significantly reduces the frequency of headache and improves the quality of life (QOL) in patients with migraine; however, the effect on migraine intensity is nonsignificant.

Major finding: Atorvastatin plus nortriptyline vs. nortriptyline alone led to a significantly lower headache frequency (P = .004) at week 24 in addition to a significant improvement in the QOL at weeks 14 and 24 (both P = .001); however, no significant difference was observed in the headache intensity over 24 weeks.

Study details: This prospective, triple-blind, randomized controlled trial included 68 adult patients with migraine who were randomly assigned to receive atorvastatin plus nortriptyline (n = 34) or placebo plus nortriptyline (n = 34) for 24 weeks.

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Disclosures: The study was supported by a grant from the Research and Technology Department of Shahid Sadoughi University of Medical Sciences, Yazd, Iran. The authors reported having no conflicts of interest.

Source: Sherafat M et al. Neurol Res. 2022 (Jan 17). Doi: 10.1080/01616412.2021