POEMS syndrome: a significant clinical response to lenalidomide

POEMS syndrome is a rare paraneoplastic syndrome whose cause is unknown. In this case of POEMS syndrome, the patient showed significant clinical improvement after treatment with lenalidomide. Of note is that although polyneuropathy is a known side effect of IMiDs, lenalidomide is an immune modulator that is cytotoxic to malignant plasma cells but has a much lower risk of peripheral neuropathy.

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