Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Plasma Methylglyoxal Levels & Diabetic CVD

Diabetes Care; ePub 2018 May 21; Hanssen, et al

Plasma methylglyoxal (MGO) and glyoxal (GO) levels are associated with cardiovascular disease (CVD) mortality in individuals with type 2 diabetes, a recent study found. The study included 1,003 participants (mean age 59.1 years, 69.3% male, 61.6% with prior CVD) with type 2 diabetes. Researchers measured plasma MGO levels and 2 other dicarbonyls (GO and 3-deoxyglucosone) as baseline with mass spectrometry. Mean follow-up of CVD events was 8.6 years. Among the findings:

  • 287 individuals suffered from at least 1 CVD event; 346 died, and 60 underwent an amputation.
  • Higher MGO levels were associated with total and fatal CVD and with all-cause mortality, myocardial infarction, and amputations.
  • MGO levels were not associated with stroke.
  • Higher GO levels were significantly associated with fatal CVD, but not with other outcomes.


Hanssen NMJ, Westerink J, Scheijen JJM, et al. Higher plasma methylglyoxal levels are associated with incident cardiovascular disease and mortality in individuals with type 2 diabetes. [Published online ahead of print May 21, 2018]. Diabetes Care. doi:10.2337/dc18-0159.

This Week's Must Reads

Obesity Prevalence Among US Adults, JAMA; 2018 Jun 19; Hales, Fryar, et al

Screening for Osteoporosis to Prevent Fractures, JAMA; ePub 2018 Jun 26; US Preventive Services Task Force

Chocolate Intake & Incident CHD in Women , Am J Clin Nutrit; ePub 2018 Jun 21; Greenberg, et al

Site of Death & Patterns of Care in Older Adults, JAMA; ePub 2018 Jun 25; Teno, Gozalo, et al

Medications Don’t Slow T2D Progression in Youth, Diabetes Care; ePub 2018 Jun 25; RISE Consortium

Must Reads in Cardiology

Chocolate Intake & Incident CHD in Women , Am J Clin Nutrit; ePub 2018 Jun 21; Greenberg, et al

Stress & CV Health in Among Blacks, J Am Heart Assoc; ePub 2018 Jun 5; Brewer, et al

ECG Screening for CVD in Low-Risk Patients, JAMA; 2018 Jun 12; Curry, US Preventive Task Force

Racial Differences Between Estimated CRF & Stroke, Mayo Clin Proc; ePub 2018 Jun 11; Sui, et al

Relevance of Health Literacy to CV Health, Circulation; ePub 2018 Jun 4; Magnani, et al