Spencer E. Szczesny, MS, Chang Soo Lee, MD, and Louis J. Soslowsky, PhD
Mr. Szczesny is Graduate Student, McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, and Bioengineering Department, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania.
Dr. Lee is Visiting Scholar, McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, and Assistant Professor, Department of Orthopaedic Surgery, Inje University Ilsanpaik Hospital, Goyang-si, Gyeonggi-do, Korea.
Dr. Soslowsky is Fairhill Professor of Orthopedic Surgery, McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, and Professor of Bioengineering, Bioengineering Department, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania.
Orthopedic tissues respond to mechanical loads to maintain normal homeostasis and in response to injury. As the body of work on this continues to grow, it is important to synthesize the recent studies across tissues and specialties with one another and with past studies. Hence, this review highlights the knowledge gained since 2000, with only few exceptions, concerning the effects of mechanical load and biologics on remodeling and repair of orthopedic tissue.
