Regular vitamin E supplementation may help alleviate joint discomfort in RA

Key clinical point: Regular vitamin E supplementation in patients with rheumatoid arthritis (RA) may help reduce joint discomfort, edema, and stiffness, thus enhancing the overall quality of life.

Major finding: Patients with RA who received regular vitamin E supplementation showed improvements in uncomfortable joints (mean difference [MD] −0.62; 95% CI −12.59 to 11.36) and tender joints (MD −1.66; 95% CI −6.32 to 2.99) compared with those who received placebo, fish oil, or other medications, without any significant safety concerns.

Study details: This was a systematic review and meta-analysis of nine studies including 39,845 individuals with RA who received vitamin E (experimental group) or placebo, fish oil, or other medications (control group).

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Disclosures: This study was supported by funding from the Natural Science Foundation of Shaanxi Province, China. The authors declared no competing interests.

Source: Kou H et al. Effect of vitamin E supplementation in rheumatoid arthritis: A systematic review and meta-analysis. Eur J Clin Nutr. 2022 (Apr 25). Doi: 10.1038/s41430-022-01148-9