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Oral Anticoagulants and Nonvalvular A-fib: A Balancing Act

Clinician Reviews. 2015 February;25(2):26-32
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Patients with nonvalvular atrial fibrillation (A-fib) have a fivefold greater risk for ischemic stroke than those without. Newer oral anticoagulants reduce this risk—but also increase risk for serious bleeding, including intracranial hemorrhage. Here are the evidence-based guidelines to help you make the choice that’s best for your patient.

CONCLUSION
Nonvalvular A-fib is a common arrhythmia that contributes significantly to morbidity among older adults. Use of the most current clinical practice guidelines coupled with patient education will improve overall patient outcomes.

* Editor's note: At press time, the FDA had announced approval of another oral anticoagulant, edoxaban, for the reduction of stroke and systemic embolism risks in nonvalvular A-fib.