In the Literature: Research You Need to Know
Citation: Romano M, Cuomo A, Gravina AG, et al. Empirical levofloxacin-containing versus clarithromycin-containing sequential therapy for Helicobacter pylori eradication: a randomised trial. Gut. 2010;59(11):1465-1470.
B-D-GLUCAN ASSAY USEFUL FOR DIAGNOSIS OF INVASIVE FUNGAL INFECTIONS
This meta-analysis of 16 studies shows that B-D-glucan assay had 76.8% sensitivity and 85.3% specificity in diagnosing invasive fungal infections, excluding pneumocystis jirovecii infections.
Citation: Karageorgopoulos DE, Vouloumanou EK, Ntziora F, Michalopoulos A, Rafailidis PI, Falagas ME. B-D-glucan assay for the diagnosis of invasive fungal infections: a meta-analysis. Clin Infect Dis. 2011;52(6):750-770.
CLINICAL PHARMACIST SERVICE MIGHT IMPROVE QUALITY OF PRESCRIBING AND PATIENT-HEALTH-RELATED QUALITY OF LIFE
This randomized, controlled trial showed that a clinical pharmacist service on an impatient medical ward improved health-related quality of life by some measures and significantly decreased potentially inappropriate prescribings per patient.
Citation: Bladh L, Ottosson E, Karlsson J, Klintberg L, Wallerstedt SM. Effects of a clinical pharmacist service on health-related quality of life and prescribing of drugs: a randomised controlled trial. BMJ Qual Saf. 2011 Jan. 5 [Epub ahead of print].
Tako-Tsubo Cardiomyopathy Is Associated with Higher Hospital Readmission Rates and Long-Term Mortality
Clinical question: What is the natural history of patients who develop tako-tsubo cardiomyopathy?
Background: Stress-induced or tako-tsubo cardiomyopathy (TTC) is a rare acute cardiac syndrome, characterized by chest pain or dyspnea, ischemic electrocardiographic changes, transient left ventricular (LV) dysfunction, and limited release of cardiac injury markers, in the absence of epicardial coronary artery disease (CAD). The long-term outcome of this condition is unknown.
Study design: Prospective, case-control study.
Setting: Five urban-based hospitals in Italy.
Synopsis: One hundred-sixteen patients with TTC were included in the five-year study period. Patients were followed up at one and six months, then annually thereafter. Primary endpoints were death, TTC recurrence, and rehospitalization for any cause.
Mean initial LV ejection fraction (LVEF) was 36%. Two patients died of refractory heart failure during hospitalization. Of the patients who were discharged alive, all except one showed complete LV functional recovery.
At follow-up (mean two years), only 64 (55%) patients were asymptomatic. Rehospitalization rate was high (25%), with chest pain and dyspnea the most common causes. Only two patients had a recurrence of TTC. Eleven patients died (seven from cardiovascular causes). There was no significant difference in mortality or in other clinical events between patients with and without severe LV dysfunction at presentation. The standardized mortality ratio was 3.40 (95% CI, 1.83-6.34) in the TTC population, compared with the age- and sex-specific mortality of the general population.
The study is limited by a lack of patients with subclinical TTC disease and those who might have suffered from sudden cardiac death prior to enrollment, leading to a possible sampling bias, as well as the nonrandomized use of beta-blockers.
Bottom line: Tako-tsubo disease is associated with rare recurrence of the disease, common recurrence of chest pain and dyspnea, and three times the mortality rate of the general population.
Citation: Parodi G, Bellandi B, Del Pace S, et al. Natural history of tako-tsubo cardiomyopathy. Chest. 2011;139(4):887-892.
Seven Independent Risk Factors Predict Postoperative Pulmonary Complications
Clinical question: What are the clinical risk factors that predict higher rates of postoperative pulmonary complications?
