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In the Literature: The latest research you need to know

The Hospitalist. 2011 September;2011(09):

Background: Resident work-hour limitations require new models of care for hospitalized patients. Many academic medical centers have hired physician assistants to work with hospitalists to provide care. Little is known about how these models affect such outcomes as LOS, inpatient mortality rates, and readmission rates.

Study design: Retrospective cohort.

Setting: A 430-bed urban academic medical center in Milwaukee.

Synopsis: Administrative data were gathered on 9,681 patients admitted to the general medical service. Of those enrolled, 2,171 were cared for by a hospitalist-physician assistant (H-PA) team, while resident-hospitalist teams cared for 7,510 patients. Patient assignment was dependent on time of admission but not on patient complexity. Patients admitted overnight after the resident team capped were assigned to the H-PA team the next morning, resulting in increased transitions of care for the H-PA team.

Adjusted analyses revealed a 6.45% increase in LOS for the H-PA team compared with the resident team. Charges, inpatient mortality, and readmission rates at seven, 14, and 30 days were unchanged. Subgroup analyses revealed smaller differences in LOS for H-PA teams and resident-hospitalist teams with the same hospitalist (LOS 5.44% higher, P=0.081).

Conclusions from this study are limited due to lack of randomization of assignment, the retrospective design, and the use of administrative data at one institution.

Bottom line: Hospitalist-PA teams might result in a slightly increased LOS compared with the traditional resident teams; however, inpatient mortality and readmission rates are similar.

Citation: Singh S, Fletcher KE, Schapira MM, et al. A comparison of outcomes of general medical inpatient care provided by a hospitalist-physician assistant model vs a traditional resident-based model. J Hosp Med. 2011;6:122-130.

CLINICAL SHORTS

HIGH LEVELS OF STRESS AND BURNOUT ARE FOUND AMONG ACADEMIC HOSPITALISTS

In a survey of 266 academic hospitalists, 67% reported high levels of stress and 23% reported some degree of burnout.

Citation: Glasheen JJ, Misky GJ, Reid MB, Harrison RA, Sharpe S, Auerbach A. Career satisfaction and burnout in academic hospital medicine. Arch Intern Med. 2011;171(8):782-785.

PROTON PUMP INHIBITORS (PPIS) INCREASE FRACTURE RISK

This meta-analysis demonstrated that use of PPIs, but not H2-blockers, is associated with increased risk of spine, hip, and all-site fractures in men and women.

Citation: Yu EW, Bauer SR, Bain PA, Bauer DC. Proton pump inhibitors and risk of fractures: a meta-analysis of 11 international studies. Am J Med. 2011;124:519-526.

ERYTHROPOIETIN INFUSION AFTER STEMI DID NOT DECREASE INFARCT SIZE

Randomized controlled trial showed that erythropoietin infusion within four hours of percutaneous coronary intervention did not decrease infarct size and was associated with an increased rate of adverse cardiovascular events.

Citation: Najjar SS, Rao SV, Melloni C, et al. Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. JAMA. 2011;305(18):1863-1872.

SURGERY OR PPIS TREAT REFLUX LONG-TERM

Both laparoscopic antireflux surgery and long-term acid suppression yield high five-year remission rates for patients with GERD, though each group has differing side effects of therapy.

Citation: Galmiche JP, Hatlebakk J, Attwood S, et al. Laparoscopic antireflux surgery vs esomeprazole treatment for chronic GERD: the LOTUS randomized clinical trial. JAMA. 2011;305(19):1969-1977.

SODIUM POLYSTYRENE SULFONATE (KAYEXALATE) DOSE MAY IMPACT REDUCTION IN SERUM POTASSIUM

Retrospective cohort study suggests a dose response relationship with reduction in serum potassium, with the mean decrease in potassium concentration of 0.99 mmol/L after a single dose.

Citation: Kessler C, Ng J, Valdez K, Xie H, Geiger B. The use of sodium polystyrene sulfonate in the inpatient management of hyperkalemia. J Hosp Med. 2011;6(3):136-140.

SWITCHING TO $4 DRUG PLANS COULD SAVE BILLIONS

Retrospective analysis revealed that patients could save $115 per year ($5.78 billion total) by switching to $4 generic drugs at retail store pharmacies.

Citation: Zhang Y, Zhou L, Gellad W. Potential savings from greater use of $4 generic drugs. Arch Intern Med. 2011;171(5):468-469.