Hurricane Maria, Bloodstream Infections, Lung Cancer in Women

The presence of progesterone receptors is associated with longer survival in NSCLC, and treatment with progesterone has been shown to induce apoptosis and inhibit migration and invasion of lung cancer cell lines (Ishibashi et al. Cancer Res. 2005;65[14]:6450). Women over the age of 60 were found to have significant survival benefit when compared with both men and younger women (Wakelee et al. J Thoracic Oncol. 2007b; 2:S570), whereas a worse survival and earlier age of occurrence of lung cancer was associated with the exposure to HRT (Ganti et al. J Clin Oncol. 2006;24[1]:59).

The future of hormone receptor targets in lung cancer may provide new therapeutic options for patients with lung adenocarcinoma, especially those with acquired resistance to the EGFR antagonists (Hsu et al. Int J Mol Sci. 2017; 18[8] pii: E1713. doi: 10.3390/ijms18081713).

Fidaa Shaib, MD, FCCP
Steering Committee Member

Ali Jiwani, MD
NetWork Member