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The controversy over long-acting beta agonists: Examining the evidence

Cleveland Clinic Journal of Medicine. 2006 November;73(11):973-976, 978, 981-984, 986, 989, 992
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ABSTRACTIn the Salmeterol Multicenter Asthma Research Trial (SMART), patients receiving the long-acting beta agonist salmeterol—particularly African Americans—had a statistically significantly higher risk of fatal or potentially fatal asthma episodes. As a result, medications that contain salmeterol (Serevent, Advair) or formoterol (Foradil) carry a "black box warning." However, the benefits of these drugs continue to outweigh the risks, if they are used appropriately.