Diabetes insipidus: Diagnosis and treatment of a complex disease
Amgad N. Makaryus, MD
North Shore University Hospital, New York University School of Medicine, Manhasset, NY
Samy I. McFarlane, MD, MPH
State University of New York-Downstate and Kings County Hospital Center, Brooklyn, NY
Address: Samy I. McFarlane, MD, Department of Medicine, Box 50, State University of New York Health Science Center at Brooklyn, Kings County Hospital Center, 450 Clarkson Avenue, Brooklyn, NY 11203; e-mail Samy.McFarlane@downstate.edu
ABSTRACTDiabetes insipidus, characterized by excretion of copious volumes of dilute urine, can be life-threatening if not properly diagnosed and managed. It can be caused by two fundamentally different defects: inadequate or impaired secretion of antidiuretic hormone (ADH) from the posterior pituitary gland (neurogenic or central diabetes insipidus) or impaired or insufficient renal response to ADH (nephrogenic diabetes insipidus). The distinction is essential for effective treatment.