Familial hypercholesterolemia: A challenge of diagnosis and therapy
Christopher Sibley, MD
Department of Cardiology, Johns Hopkins University, Baltimore, MD
Neil J. Stone, MD
Professor of Clinical Medicine, Feinberg School of Medicine, Northwestern University,
Address: Neil Stone, MD, Feinberg School of Medicine, Northwestern University, 211 E. Chicago Avenue, Suite 1050, Chicago, IL 60611; e-mail email@example.com
Dr. Stone has indicated that he serves as a consultant for and has given educational talks sponsored by the Abbott, Merck, Merck-Schering, Pfizer, Reliant, and Sonosite corporations.
ABSTRACTPeople with familial hypercholesterolemia (FH) have dramatically high levels of low-density lipoprotein cholesterol (LDL-C), which can lead to accelerated atherosclerosis and, if untreated, early cardiovascular death. Although the heterozygous form of FH is often unrecognized, detecting it early can enable risk reduction before premature coronary heart disease occurs.