Interstitial Cystitis

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Although there are numerous reports in the literature dealing with the subject of interstitial cystitis, our experience justifies the statement that this disease is recognized too infrequently by the general profession, and that patients are too commonly subjected to diverse surgical attacks in a futile attempt to remove a most distressing pain, or even worse, they are classified as neurotics and denied proper investigation.

This disease was first described by Hunner in 1914, and therefore is frequently referred to as Hunner’s ulcer, but it has also been termed submucous cystitis, panmural cystitis, elusive ulcer, etc. Interstitial cystitis, however, is a more descriptive title. Although originally described as a rare type of bladder ulcer, increased recognition has shown that it is not an infrequent lesion, and in the past fifteen years we have encountered 70 cases. It is preponderately a disease of females, 90 per cent of our cases having occurred in this sex. The majority appeared between the ages of 40 and 70, the extremes in our cases being 18 and 77 years of age. Of the 63 women, 10 were unmarried, while of the 53 who were married, 31 had borne children and 22 had not.

The etiology of this disease is quite unknown. In his original paper, Hunner suggested that focal infection might be the cause, and Bumpus and Meisser reported that they had reproduced the lesion in the bladders of rabbits injected with cultures obtained from the teeth and tonsils of patients suffering from the disease. Later,. . .



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