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Emphysema in nonsmokers: Alpha 1-antitrypsin deficiency and other causes

Cleveland Clinic Journal of Medicine. 2002 December;69(12):928-929, 933, 936, 939, 943-946
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ABSTRACTNonsmokers with signs of emphysema at an earlier age than is typical for emphysema deserve a workup for one of the less common causes of emphysema, which include alpha 1-antitrypsin deficiency, connective tissue diseases, hypocomplementemic urticarial vasculitis syndrome, intravenous drug use, human immunodeficiency virus infection, and several rare metabolic disorders.