Interpreting Key Trials

Alpha-blockers and congestive heart failure: Early termination of an arm of the ALLHAT trial

Author and Disclosure Information


The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is a large, randomized double-blind study comparing four antihypertensive agents (chlorthalidone, doxazosin, amlodipine, and lisinopril) in hypertensive patients older than 55 years. The doxazosin arm was terminated early, when the trial's safety and monitoring board noted a twofold higher incidence of congestive heart failure in patients receiving doxazosin than in those receiving chlorthalidone (8.13% vs 4.45% at 4 years, P < .001).


Next Article:

‘Rescue’ angioplasty for failed thrombolysis

Related Articles