The diagnostic utility of c-ANCA in Wegener’s granulomatosis
GARY S. HOFFMAN, MD
CAROL A. LANGFORD, MD, MHSADDRESS: Carol A. Langford, MD, MHS, Building 10, Room 11B-13, National Institutes of Health, Bethesda, MD, 20892.
Anti-neutrophil cytoplasmic antibodies with a cytoplasmic staining pattern (c-ANCA) have been found to have a high degree of sensitivity and specificity for Wegener’s granulomatosis. Nevertheless, despite the attraction of using this autoantibody as a diagnostic test, in almost all instances it should not be used in place of a biopsy to diagnose Wegener’s granulomatosis.