Interpreting Key Trials

High or low doses of ACE inhibitors for heart failure?

Results of the ATLAS study

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In a large, randomized study, patients with heart failure who received a large daily dose of an angiotensin-converting inhibitor had a trend toward a lower mortality rate than did patients who received a low daily dose. Moreover, the hospitalization rate was lower in the high-dose group, and the side-effect profile was the same in both groups. Physicians should try to give maximal closes to achieve optimum benefit in this patient population.


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