Homocysteine: Update on a new risk factor
RAJ S. BALLAL, MD
Department of Cardiology, Cleveland Clinic.
DONALD W. JACOBSEN, PhD
Department of Cell Biology, Cleveland Clinic; Professor of Chemistry, Cleveland State University. His research interests are the relationship between homocysteine and cardiovascular disease and the effects of homocysteine on the vascular endothelium
KILLIAN ROBINSON, MD
Department of Cardiology, Cleveland Clinic. He specializes in research on the relationship between homocysteine and vascular disorders.
A high fasting plasma homocysteine level is an independent risk factor for atherosclerosis and venous thrombosis. Vitamin therapy can lower homocysteine levels, but no benefit has yet been demonstrated; studies using clinical outcomes as endpoints are now in progress.