Lipid and lipoprotein abnormalities in lower-extremity arteriosclerosis obliterans
Jeffrey W. Olin, DOAddress reprint requests to J.W.O., Department of Vascular Medicine, S60, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195.
Michael D. Cressman, DO
Jess R. Young, MD
Byron J. Hoogwerf, MD
Cheryl E. Weinstein, MD
The prevalence of abnormal lipid and lipoprotein values was determined in 125 consecutive patients with lower-extremity arteriosclerosis obliterans, and the lipid and lipoprotein abnormalities in these patients were characterized. Only 13% of the patients had normal lipid/lipoprotein profiles. Forty-eight percent of patients had low levels of high-density lipoprotein cholesterol. High-density lipoprotein cholesterol values were lower in patients with concomitant coronary heart disease compared with those without heart disease. High-density lipoprotein cholesterol values were inversely related to weight, to triglyceride values, and to diabetes mellitus. Twenty-eight percent of patients had “desirable” total cholesterol levels (<200 mg/dL), and 32% had low-density lipoprotein cholesterol values less than 130 mg/dL. Following National Cholesterol Education Program guidelines may be misleading in patients with documented lower-extremity atherosclerosis; therefore, complete lipid/lipoprotein profiles should be performed in these patients.