Experimental limbic epilepsy: models, pathophysiologic concepts, and clinical relevance
Mohamed Nayel, MD
Issam A. Awad, MDAddress reprint requests to I.A.A., Department of Neurosurgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195.
Mark Larkins, MD
Hans Lüders, MD, PhD
Complex partial seizures originating in the temporal lobe are one of the most common types of seizures in patients with epilepsy. They are frequently intractable to medical treatment and are increasingly considered for surgical therapy. These seizures are often associated with focal epileptogenicity in limbic structures (amydgala and hippocampus) or with rapid spread of seizure activity to these areas. Much research is being undertaken to better understand this disorder and to develop more effective approaches to diagnosis and treatment. Experimental work in animals has contributed to the understanding of epileptogenesis, the interictal state, and the homeostatic mechanisms that limit seizure activity.