Immunoglobulin therapy in infectious disease
James E. Pennington, MDAddress reprint requests to J.E.P., Director, Department of Medical Research, Cutter Biological, P.O. Box 1986, 4th and Parker Streets, Berkeley, CA 94701.
The role of immunoglobulin therapy in the prevention and treatment of infectious disease has been greatly expanded by the ability to administer immunoglobulins intravenously. Neonates, patients with AIDS, and bone marrow transplant recipients are beneficiaries of the advances being made in IgG therapy. Studies suggest that the synergistic effect of a combination of antibiotics and antibodies will be useful in the future. Other future directions for antibody therapy include development of monoclonal antibodies for treatment of sepsis. Also, clinical trials of monoclonal antibody against tumor necrosis factor are setting the stage for monoclonal antibody research directed increasingly to the anti-mediator concept.