The clinical challenge of Lyme disease
David L. Longworth, MDAddress reprint requests to D.L.L., Department of Infectious Disease, The Cleveland Clinic Foundation, One Clinic Center, 9500 Euclid Avenue, Desk S32, Cleveland, Ohio 44195-5215
Lyme disease is a systemic infection with protean clinical manifestations. In the past decade the disease has evolved from a medical curiosity to the most common vector-borne disease in the United States. The diverse clinical manifestations together with the lack of standardized serologic tests pose a significant diagnostic challenge for the practicing physician. The epidemiology, clinical presentation, diagnosis, and recommended therapy of Lyme borreliosis are reviewed.