Donald R. Steinmuller, MDAddress reprint requests to D.R.S., Department of Hypertension and Nephrology, The Cleveland Clinic Foundation, One Clinic Center, 9500 Euclid Avenue, Cleveland, Ohio 44195.
Cyclosporine is a potent and useful immunosuppressive agent used primarily in Conjunction with solid organ transplantation. The most serious adverse reaction that limits its use is nephrotoxicity due to effects on the renal vasculature, glomeruli, and tubular function. These effects result in a variety of clinical syndromes. This review outlines the clinical syndromes and discusses ways to minimize nephrotoxicity in patients receiving cyclosporine.