LESLIE R. SHEELER, MD, FACP
Department of Endocrinology, The Cleveland Clinic Foundation, One Clinic Center, 9500 Euclid Avenue, Cleveland, Ohio 44195
Despite major advances in laboratory methods, radiology, and neurosurgery, the evaluation and therapy of Cushing's syndrome remains a major challenge to clinicians. In a substantial percentage of the patients with Cushing's syndrome, laboratory and radiologic studies yield data that are confusing or misleading. This paper reviews the various disorders that comprise Cushing's syndrome and addresses some of the problems in diagnosis and therapy.