Benign essential blepharospasm treated with botulinum toxin1

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Blepharospasm in 12 patients was graded according to its severity. Six patients also underwent neurological and psychological examinations. All were treated with periocular botulinum toxin injections, and all noted a reduction in spasm severity one week later. The effect lasted 60 to 90 days. The average improvement range was 2 gradations of spasm severity. Complications included a transient ptosis (two patients) and superficial punctate keratopathy (one patient). A psychological component—apparent secondary gain from the blepharospasm—was noted in three patients.



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