Commentary

Immunological reversal of digitalis toxicity by Fab fragments of digoxin-specific antibodies1

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Abstract

Severe digitalis toxicity is associated with a high mortality. We present a case of advanced digoxin toxicity successfully treated with digoxin-specific antibody Fab fragments, and discuss its mechanism of action. A review of the pharmacokinetics of digitalis as well as the mechanisms of cardiotoxicity and its conventional treatment is presented.


 

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