Analytical electron microscopy in pneumoconiosis1

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The study of pneumoconiosis has been greatly facilitated by use of the analytical electron microscope. Morphologic, crystallographic, and chemical analyses may be obtained on submicroscopic particles using various analytical modalities. Since there is no destruction of tissue, as in other analytical techniques, analytical electron microscopy can help relate the effects of foreign particles to localized cell and tissue reactions. An overview of the different modalities of the analytical electron microscope is presented, along with cases illustrative of their use.