Proposed pathogenesis of fibrositis1

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While the pathogenesis of fibrositis is not clearly understood, it is useful to consider it as a disorder of pain modulation which is due at least in part to deficient concentrations of certain amines in the central nervous system. Any clinical entity which interferes with stage IV sleep (as indicated by disturbed delta wave patterns), whether “psychogenic” or “organic,” can cause fibrositis. Thus it is not appropriate to speak of “primary” and “secondary” forms of the disease. The large number of persons who suffer from the pain, fatigue, depression, and anxiety associated with fibrositis mandate further investigations into its causes and treatment.